Beilstein J. Org. Chem.2021,17, 203–209, doi:10.3762/bjoc.17.20
to access aziridines with great structural variability [21]. The reaction of azirines with Grignard and organolithium reagents has been poorly investigated, and only without using green and renewablesolvents [22][23]. In turn, 2H-azirines can be smoothly obtained through intramolecular cyclization
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Graphical Abstract
Scheme 1:
Flow generation and transformation of 2H-azirines.
Beilstein J. Org. Chem.2015,11, 622–627, doi:10.3762/bjoc.11.70
tetrasubstituted enamines. The use of the sustainable and environmentally benign solvent (R)-limonene for the reaction is also reported with the amine isolated by acid extraction.
Keywords: alkenes; homogeneous catalysis; hydrogenation; renewablesolvents; tertiary amines; Introduction
A potentially very direct
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Graphical Abstract
Scheme 1:
Synthesis of enamines from ketones with percentage yields.